10. How did I let this happen again? (2008)
In 2004 Oprah celebrated slimming down to 75 kilograms, and championed her "foolproof formula for permanent weight loss". Then, "life took over". By 2008, she had returned to 90 kilograms, and in true Oprah fashion, instead of hiding it, she confronted the elephant in the room (no pun intended). At first she blamed a thyroid problem and a killer schedule, before taking full responsibility for hopping off the weight-loss bandwagon.