"It's gonna be my last," he told Italy's Vanity Fair. "I do not know what's going to happen to the other characters, but for me it's done... it's been great and a great part of my life. But I can't see me doing it anymore."
Dempsey plays Dr Derek "McDreamy" Shepherd, one half of the hospital soap's most iconic couple. McDreamy finally married his long-time love Meredith Grey (Ellen Pompeo) at the end of season five, and the current seventh season has chronicled their attempts to start a family.
But if Derek exits, it doesn't mean he'll break it off with Meredith — Pompeo's contract also expires at the end of season eight, sparking speculation she'll also quit the show that bears her character's name.